Superfine pulverization technology is a new technology that has emerged in the past decade. It has greatly extended the concept of smashing on the basis of traditional smashing technology. Advanced Micro Devices mill in a variety of mechanical equipment, currently with jet mill and mechanical mill in the pharmaceutical industry is widely used in the fluidized bed jet mill again airflow ultrafine mill application zui wide, In the mechanical pulverizer, the effect of the heavy-pressure grinding type is also good.
In the process of drug production, when the solid material is ultra-finely pulverized to a size of micron or even nanometer, the physical and chemical properties of the substance will be greatly changed, thereby significantly improving the dissolution of the drug and reducing the drug. toxic side effect. Both internal and external use can significantly improve the efficacy. Especially in the field of traditional Chinese medicine, ultra-fine pulverization technology can change the traditional Chinese medicine method. After the ultra-fine pulverization and refinement, the Chinese medicinal materials can be directly used for oral administration, thus eliminating the cumbersome process such as decoction pieces and boiling, which greatly facilitates the patient. Medication.
Not only that, the research shows that the amount of Chinese medicine used in ultra-fine refining is only one tenth of the amount of the original prescription, which greatly saves valuable Chinese herbal medicine resources and effectively protects the cultivation environment of Chinese herbal medicines. In addition, through the ultra-fine pulverization technology, the effective product which is insoluble or slightly soluble in water can significantly improve the bioavailability of the drug through cell wall breaking. This has opened up a new way for Chinese medicine to go global. As a new technology, the ultra-fine pulverization technology was gradually taken seriously by relevant research departments and the pharmaceutical industry in China in the 1990s. Many of the theories of this technology are still in the stage of continuous exploration. With the continuous improvement and development of measurement technology and pulverization theory, "superfine pulverization technology and ultrafine pulverizer" will be more widely used in the pharmaceutical field in China.
When choosing to use the superfine pulverizer , its control must meet the following requirements:
1. Optimize the hierarchical structure. Grading is a crucial part of the ultrafine pulverizing system. A remarkable feature of the ultrafine pulverizer is that it can realize continuous feeding and discharging, preventing excessive pulverization of materials and unnecessary energy consumption. Appropriately increase the diameter of the classifying wheel, increase the rotation speed, and reduce the air flow to ensure that the separation particle size of the classifier is small.
2. A screw feeder, an oscillating feeder or a star feeder can be used to ensure that the energy source in the pulverizing chamber is continuously supplied with materials to meet the material concentration in the pulverizing chamber.
3, advanced dual-frequency control technology, so that the machine's control can reach a higher level, the material's discharge speed and fineness have been greatly improved.
4. The original material entering the superfine pulverizer should be as small as possible. In order to achieve this, pre-pulverization treatment should be carried out using an ordinary mechanical pulverizer before superfine pulverization, which is a direct and effective method for saving energy and increasing unit yield.
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