Effective Small-Molecule Inhibitor Afatinib (CAS: 439081-18-2)

Model NO.: Pharmaceutical Grade
Origion: Hubei, China
Brand: Newbio Pharmtech
Market: Global
Trademark: NEWBIO PHARMTECH
Transport Package: Aluminum Foil Bags or Fiber Drum
Specification: SGS/ CTI/ ITS
Origin: Wuhan, Hubei, China
HS Code: 8676530000
Model NO.: Pharmaceutical Grade
Origion: Hubei, China
Brand: Newbio Pharmtech
Market: Global
Trademark: NEWBIO PHARMTECH
Transport Package: Aluminum Foil Bags or Fiber Drum
Specification: SGS/ CTI/ ITS
Origin: Wuhan, Hubei, China
HS Code: 8676530000
Small-Molecule Targeted Anti Tumor Inhibitor API  Afatinib 
(CAS: 439081-18-2)

Chemical Information
Quick Details:
Product Name Afatinib
Molecular Formula C24H25ClFN5O3
Molecular Weight 485.94
Storage 3years in -20ºC
Targets Abl c-Src
Dosage 30 nM; intraperitoneal injection
Target EGFR (L858R) EGFR (wt) EGFR (L858R/T790M) HER2
IC50 0.4 nM 0.5 nM 10 nM 14 nM
Product Name: Afatinib
Other Names:Afatinib;(2E)-N-[4-[(3-Chloro-4-fluorophenyl)amino]-7-[[(3S)-tetrahydro-3-furanyl]oxy]-6-quinazolinyl]-4-(dimethylamino)-2-butenamide;4-[(3-chloro-4-fluorophenyl)aMino]-6-{[4-(N,N-diMethylaMino)-1-oxo-2-buten-1-yl]aMino}-7-((S)-tetrahydrofuran-3-yloxy)-quinazoline;2-ButenaMide, N-[4-[(3-chloro-4-fluorophenyl)aMino]-7-[[(3S)-tetrahydro-3-furanyl]oxy]-6-quinazolinyl]-4-(diMethylaMino)-, (2E)-;(S,E)-N-(4-((3-Chloro-4-fluorophenyl)amino)-7-((tetrahydrofuran-3-yl)oxy)quinazolin-6-yl)-4-(dime;Afatinib API;Afatinib(BIBW2992MA2);Afatinib (with 1 int.)
Model No.: ATC-136
CAS No.: 439081-18-2
Molecular Formula: C24H25ClFN5O3
Molecular Weight: 485.94
Appearance: White or Nearly White Crystalline Powder
Purity: 99%+
Product Specifications: Pharmaceutical Grade
        
Product Description
Afatinib (INN; trade name Gilotrif in the US and Giotrif in Europe, previously Tomtovok and Tovok) is a drug approved in United States, Europe, Taiwan, Mexico, Chile and Japan as well as other countries for the first-line treatment of patients with distinct types of metastatic (EGFR mutation positive) non-small cell lung carcinoma (NSCLC), developed by Boehringer Ingelheim. It acts as an irreversible covalent inhibitor of the receptor tyrosine kinases epidermal growth factor receptor (EGFR) and erbB-2 (HER2).

Applications/Usage
It has received regulatory approval for use as a treatment for non-small cell lung cancer, although there is emerging evidence to support its use in other cancers such as breast cancer.

COA Report:

Item

Requirements

Test Results

Description

Off-white powder

Off-white powder

Identification

HPLC ,NMR

Complies

Residue on Ignition

≤0.10%

0.05%

Loss on Drying

≤0.50%

0.15%

Heavy Metal

≤20ppm

<20ppm

Purity(HPLC)

≥99.0%

99.99%

Conclusion

It complies with EnterpriseStandard

FEATURED PRODUCT:
No. CAS No. Product Name
1  114977-28-5  
2  148408-66-6  
3  25316-40-9  
4  133040-01-4 Eprosartan
5  183321-74-6 Erlotinib
6  183319-69-9 Erlotinib Hydrochloride
7  159351-69-6 Everolimus
8  56296-78-7 Fluoxetine Hydrochloride
9  184475-55-6  
10  136572-09-3  
11  1441674-54-9 Ledipasvir(Acetone)
12  191732-72-6 Lenalidomide
13  21672   
14  76144-81-5 Mildronate
15  474645-27-7 Monomethyl Auristatin E
16  63121-00-6  
17  137281-23-3 Pemetrexed Disodium
18  53123-88-9 Rapamycin
19  945667-22-1 Saxagliptin Hydrate
20  709031-78-7 Saxagliptin Hydrochloride

ABOUT DELIVERY:
#1 Products can be sent out within 24 hours after payment. 
#2 Secure and discreet shipment. 
#3 Various methods for your choice, like DHL/FedExs.
 

OUR COMMITMENT:
#1 We are manufacturer with own factory and we sale this product at a best quality and low price.
#2 All product listed is available in stock, please contact the sale for more details.
#3  We have QA&QC department to guarantees the quality, product pass rate can reach 100%. 
CONTACT US:
Telephone +86-027-87002705
Mobile +86-13277093700
+86-13638641831
   
FaceBook Page https://www.facebook.com/newbiopharma/
Facebook Group https://www.facebook.com/groups/1739616069613416/
Website http://www.newbiopharm.com/
Online Store http://biocar.en.made-in-china.com/


If you want to source ...
        #1 Pharmaceutical raw material,
        #2 Oncology drug APIs,
        #3 Antibiotics or fine chemicals, 
We are a reliable manufacturer and supplier in China.

NEWBIO would like to ...
        #1 We foucus on the high purity and high quality;
        #2 We provide the raw materials at a good price;
        #3 We have the best service and we are always there for you.
Please contact us for more infomation!!!
Small-Molecule Targeted Anti Tumor Inhibitor API  Afatinib 
(CAS: 439081-18-2)

Chemical Information
Quick Details:
Product Name Afatinib
Molecular Formula C24H25ClFN5O3
Molecular Weight 485.94
Storage 3years in -20ºC
Targets Abl c-Src
Dosage 30 nM; intraperitoneal injection
Target EGFR (L858R) EGFR (wt) EGFR (L858R/T790M) HER2
IC50 0.4 nM 0.5 nM 10 nM 14 nM
Product Name: Afatinib
Other Names:Afatinib;(2E)-N-[4-[(3-Chloro-4-fluorophenyl)amino]-7-[[(3S)-tetrahydro-3-furanyl]oxy]-6-quinazolinyl]-4-(dimethylamino)-2-butenamide;4-[(3-chloro-4-fluorophenyl)aMino]-6-{[4-(N,N-diMethylaMino)-1-oxo-2-buten-1-yl]aMino}-7-((S)-tetrahydrofuran-3-yloxy)-quinazoline;2-ButenaMide, N-[4-[(3-chloro-4-fluorophenyl)aMino]-7-[[(3S)-tetrahydro-3-furanyl]oxy]-6-quinazolinyl]-4-(diMethylaMino)-, (2E)-;(S,E)-N-(4-((3-Chloro-4-fluorophenyl)amino)-7-((tetrahydrofuran-3-yl)oxy)quinazolin-6-yl)-4-(dime;Afatinib API;Afatinib(BIBW2992MA2);Afatinib (with 1 int.)
Model No.: ATC-136
CAS No.: 439081-18-2
Molecular Formula: C24H25ClFN5O3
Molecular Weight: 485.94
Appearance: White or Nearly White Crystalline Powder
Purity: 99%+
Product Specifications: Pharmaceutical Grade
        
Product Description
Afatinib (INN; trade name Gilotrif in the US and Giotrif in Europe, previously Tomtovok and Tovok) is a drug approved in United States, Europe, Taiwan, Mexico, Chile and Japan as well as other countries for the first-line treatment of patients with distinct types of metastatic (EGFR mutation positive) non-small cell lung carcinoma (NSCLC), developed by Boehringer Ingelheim. It acts as an irreversible covalent inhibitor of the receptor tyrosine kinases epidermal growth factor receptor (EGFR) and erbB-2 (HER2).

Applications/Usage
It has received regulatory approval for use as a treatment for non-small cell lung cancer, although there is emerging evidence to support its use in other cancers such as breast cancer.

COA Report:

Item

Requirements

Test Results

Description

Off-white powder

Off-white powder

Identification

HPLC ,NMR

Complies

Residue on Ignition

≤0.10%

0.05%

Loss on Drying

≤0.50%

0.15%

Heavy Metal

≤20ppm

<20ppm

Purity(HPLC)

≥99.0%

99.99%

Conclusion

It complies with EnterpriseStandard

FEATURED PRODUCT:
No. CAS No. Product Name
1  114977-28-5  
2  148408-66-6  
3  25316-40-9  
4  133040-01-4 Eprosartan
5  183321-74-6 Erlotinib
6  183319-69-9 Erlotinib Hydrochloride
7  159351-69-6 Everolimus
8  56296-78-7 Fluoxetine Hydrochloride
9  184475-55-6  
10  136572-09-3  
11  1441674-54-9 Ledipasvir(Acetone)
12  191732-72-6 Lenalidomide
13  21672   
14  76144-81-5 Mildronate
15  474645-27-7 Monomethyl Auristatin E
16  63121-00-6  
17  137281-23-3 Pemetrexed Disodium
18  53123-88-9 Rapamycin
19  945667-22-1 Saxagliptin Hydrate
20  709031-78-7 Saxagliptin Hydrochloride

ABOUT DELIVERY:
#1 Products can be sent out within 24 hours after payment. 
#2 Secure and discreet shipment. 
#3 Various methods for your choice, like DHL/FedExs.
 

OUR COMMITMENT:
#1 We are manufacturer with own factory and we sale this product at a best quality and low price.
#2 All product listed is available in stock, please contact the sale for more details.
#3  We have QA&QC department to guarantees the quality, product pass rate can reach 100%. 
CONTACT US:
Telephone +86-027-87002705
Mobile +86-13277093700
+86-13638641831
   
FaceBook Page https://www.facebook.com/newbiopharma/
Facebook Group https://www.facebook.com/groups/1739616069613416/
Website http://www.newbiopharm.com/
Online Store http://biocar.en.made-in-china.com/


If you want to source ...
        #1 Pharmaceutical raw material,
        #2 Oncology drug APIs,
        #3 Antibiotics or fine chemicals, 
We are a reliable manufacturer and supplier in China.

NEWBIO would like to ...
        #1 We foucus on the high purity and high quality;
        #2 We provide the raw materials at a good price;
        #3 We have the best service and we are always there for you.
Please contact us for more infomation!!!

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