Model NO.: C18070303
Trademark: wongpharm
Origin: China (Mainlan)
Model NO.: C18070303
Trademark: wongpharm
Origin: China (Mainlan)
physicochemical Properties of chlorogenic acidProperties: Semi-hydrate is needle-like crystallization, 110° into anhydrous compound, 25° water solubility is 4%, and the solubility in hot water is greater.
Melting Point: 205-209ºc
Spin luminosity: -36º (c=1, H2O)
Water soluble: soluble in hot water
Solubility: Easily soluble in ethanol and acetone, slightly soluble in ethyl acetate The half hydrate is a needle-like crystallization (water). 110ºC into anhydrous compounds, melting point: 208ºC,[α]20d-35.2. (c=2.8). The solubility in 25ºC water is 4%, and the solubility in hot water is greater.Easily soluble in ethanol and acetone, very slightly soluble in ethyl acetate.
Use of chlorogenic acid products
1. used as pharmaceutical raw materials and intermediates
2.has a wide range of antibacterial effects, favorable gallbladder, hemostasis, increased white blood cells and antiviral effect, with shortened blood coagulation and bleeding time.For the treatment of upper respiratory tract infection, anti-inflammatory and antipyretic, cooling blood cooling.Â
3. chlorogenic acid has antibacterial activity, the mic of Staphylococcus aureus is 400ng/ml, the inhibition of IC50 by hyaluronic acid is 1.85mmol/l, the inhibitor of glucose -6-p translocation enzyme, and the glucose excretion of non insulin dependent is too fast. The free radical scavenging activity is better than that of tocopherol and ascorbic acid, the inhibitory strength of the light radicals is 5 times times of that of Penicillium ammonia; anti-mutation, liver-protecting gall bladder, inhibit viral replication, in foreign countries, CA is used to treat liver disease, can reduce LDL, increase HDL, increase GSH content, lower cholesterol.Prevent ozone damage to the lungs.
Biological activity of chlorogenic acid
1. Antioxidant action The effect of chlorogenic acid on scavenging free radicals was in dose relation with its concentration. When the concentration of chlorogenic acid is large, the scavenging effect of three kinds of active oxygen is obvious and stable, and when the concentration is low, the scavenging effect to oxygen ion and hydroxyl hydroxyl group is not ideal, even produce certain oxidation-promoting effect, and its antioxidant activity increases with the increase of coffee acyl,That is, the two-substituted caffeic acid has a much stronger antioxidant activity than the single substituted chlorogenic acid.
2.hypoglycemic effect It was found that intravenous chlorogenic acid in rats was studied to study the relationship between the glucose tolerance and insulin resistance and the splicing variant abnormality and g-6-pase activity in the 11th-digit exon of the liver insulin receptor mRNA. The results showed that the contents of glucose and insulin in the blood were improved, and the protein and DNA content in the liver increased significantly.It is suggested that the mechanism of hypoglycemic action may be that chlorogenic acid is activated by insulin in vivo, which increases the biological effect of insulin.
3. Antibacterial action It was found that the minimum inhibitory concentrations of chlorogenic acid on Staphylococcus aureus, 2.5mg/ml and Streptococcus-free streptococcus were 1.25, respectively. It is also reported that chlorogenic acid can effectively inhibit the increase of endothelin and carbon monoxide in intestinal mucosal microvascular endothelial cells,The function of intestinal mucosa microvascular endothelial cells under the action of endotoxin has protective effect.
4. Anti-Virus effect The results showed that chlorogenic acid had a strong inhibitory effect on the common respiratory virus by using in vitro cell culture and antiviral test. In vitro, we can inhibit the virus, Coxsackie B3, adenovirus type 7, adenovirus type 3 and Coxsackie B5 virus respectively.
Chlorogenic acid also inhibited the activity of neuraminidase in canine kidney cells infected with influenza virus, and promoted Newcastle disease toxin.
Inducing the role of interferon in the whole blood cell of a stranger. physicochemical Properties of chlorogenic acid
Properties: Semi-hydrate is needle-like crystallization, 110° into anhydrous compound, 25° water solubility is 4%, and the solubility in hot water is greater.
Melting Point: 205-209ºc
Spin luminosity: -36º (c=1, H2O)
Water soluble: soluble in hot water
Solubility: Easily soluble in ethanol and acetone, slightly soluble in ethyl acetate The half hydrate is a needle-like crystallization (water). 110ºC into anhydrous compounds, melting point: 208ºC,[α]20d-35.2. (c=2.8). The solubility in 25ºC water is 4%, and the solubility in hot water is greater.Easily soluble in ethanol and acetone, very slightly soluble in ethyl acetate.
Use of chlorogenic acid products
1. used as pharmaceutical raw materials and intermediates
2.has a wide range of antibacterial effects, favorable gallbladder, hemostasis, increased white blood cells and antiviral effect, with shortened blood coagulation and bleeding time.For the treatment of upper respiratory tract infection, anti-inflammatory and antipyretic, cooling blood cooling.Â
3. chlorogenic acid has antibacterial activity, the mic of Staphylococcus aureus is 400ng/ml, the inhibition of IC50 by hyaluronic acid is 1.85mmol/l, the inhibitor of glucose -6-p translocation enzyme, and the glucose excretion of non insulin dependent is too fast. The free radical scavenging activity is better than that of tocopherol and ascorbic acid, the inhibitory strength of the light radicals is 5 times times of that of Penicillium ammonia; anti-mutation, liver-protecting gall bladder, inhibit viral replication, in foreign countries, CA is used to treat liver disease, can reduce LDL, increase HDL, increase GSH content, lower cholesterol.Prevent ozone damage to the lungs.
Biological activity of chlorogenic acid
1. Antioxidant action The effect of chlorogenic acid on scavenging free radicals was in dose relation with its concentration. When the concentration of chlorogenic acid is large, the scavenging effect of three kinds of active oxygen is obvious and stable, and when the concentration is low, the scavenging effect to oxygen ion and hydroxyl hydroxyl group is not ideal, even produce certain oxidation-promoting effect, and its antioxidant activity increases with the increase of coffee acyl,That is, the two-substituted caffeic acid has a much stronger antioxidant activity than the single substituted chlorogenic acid.
2.hypoglycemic effect It was found that intravenous chlorogenic acid in rats was studied to study the relationship between the glucose tolerance and insulin resistance and the splicing variant abnormality and g-6-pase activity in the 11th-digit exon of the liver insulin receptor mRNA. The results showed that the contents of glucose and insulin in the blood were improved, and the protein and DNA content in the liver increased significantly.It is suggested that the mechanism of hypoglycemic action may be that chlorogenic acid is activated by insulin in vivo, which increases the biological effect of insulin.
3. Antibacterial action It was found that the minimum inhibitory concentrations of chlorogenic acid on Staphylococcus aureus, 2.5mg/ml and Streptococcus-free streptococcus were 1.25, respectively. It is also reported that chlorogenic acid can effectively inhibit the increase of endothelin and carbon monoxide in intestinal mucosal microvascular endothelial cells,The function of intestinal mucosa microvascular endothelial cells under the action of endotoxin has protective effect.
4. Anti-Virus effect The results showed that chlorogenic acid had a strong inhibitory effect on the common respiratory virus by using in vitro cell culture and antiviral test. In vitro, we can inhibit the virus, Coxsackie B3, adenovirus type 7, adenovirus type 3 and Coxsackie B5 virus respectively.
Chlorogenic acid also inhibited the activity of neuraminidase in canine kidney cells infected with influenza virus, and promoted Newcastle disease toxin.
Inducing the role of interferon in the whole blood cell of a stranger.
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