Release date: 2016-01-06
A new breakthrough device has been developed that significantly reduces the cost of precision laboratory testing for medical conditions such as human immunodeficiency virus (HIV), Lyme disease and syphilis.
Immunoassays are widely used because they energize a large variety of biomolecules associated with clinical diagnosis, and, in the near term, immune abilities have been improved by developing multiple assays while simultaneously detecting multiple analytes in a single sample.
Biomedical engineers at Rutgers, The State University of New Jersey (USA) have developed wafer devices that use microfluidics and make them more affordable for patients and scientists. This device opens the door to new inspections because it allows for complex analysis using samples that are 90% less than the sample required for routine testing. Traditionally tested chemicals cost as much as $1,500, and the cost of this breakthrough technology is only one-tenth of the cost. In addition, the equipment is automated, freeing most of the skilled technicians required for traditional inspections.
The team developed a multiplex immunoassay with the necessary features to use all available reagents to easily detect changes in analytes of interest. The device demonstrated was able to simultaneously detect 6 proteins in 32 samples with a sample volume of only 4.2 microliters. The high quality standard curve was generated from all six analytes included in the analysis, and the spiked samples were quantified over the entire working range of the test. They also showed that the use of equipment to detect in vitro supernatants was strongly correlated with the results obtained by benchtop multiplex immunoassays.
The researchers also described the release of cytokines from the in vitro immunized hippocampal culture system and established proof of the ability to use this platform as an in vitro screening tool. The microdevices described in the study have the ability to perform multiple inspections using low-volume inspections, and can be widely used in a variety of situations where sample volume and cost are limited.
Dr. Martin L. Yarmush, Distinguished Professor of Biomedical Engineering and Senior Author of the Study, said, “The sensitivity and accuracy of using this device is the same as that of standard benchtop equipment. Using our technology, researchers will be able to A wide range of controlled studies is comparable to the accuracy of traditional assays. The study was originally published in the online version of the Lab on a Chip magazine on July 1, 2015.
Source: LabMedia
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