The role of sessile five plus

Sessile five plus

Anti-inflammatory effect: The root bark of sessile quinquefolius produced in Liaoning, and non-defatted and defatted preparations extracted with ethanol, inhibited egg whiteness and formaldehyde-induced arthritis in rats, and subcutaneous injection of non-degreased 0.75 for 5 consecutive days. Inhibition of egg white swelling at g/kg/day was similar to the inhibition of 7.5 mg/kg/day of cortisone administered intramuscularly for 5 consecutive days. Non-degreased preparations were injected subcutaneously or intraperitoneally into rats with adrenalectomy, and there was no inhibitory effect on egg white swelling. Therefore, the anti-inflammatory effects of short stems and five additions were closely related to the adrenal glands. In addition, short-stemmed five-can also reduce rabbit vascular permeability.

(2) Analgesic and antipyretic effects: The mice were injected intraperitoneally with the above two preparations and all showed analgesic effects. Compared with morphine, the effects were milder, but there was no antipyretic effect in rabbits.

(3) Cardiovascular effects: Non-degreased preparations have a significant inhibitory effect on isolated hearts, whereas in the case of axillary tendons, the heart rate is slowed down. The defatted preparation reduces the frequency of the isolated heart and only the amplitude of the resident heart. cut back. Both preparations can reduce blood pressure in anesthetized rabbits.

(4) Other effects: The two preparations have excitatory effects on the isolated intestine and uterus of rabbits, and the uterus is more sensitive to pregnancy. There is mild activation of the electroencephalogram of normal rabbits. For example, the activity of Acanthopanax senticosus is 40-140 times stronger than that of a liquid extract. It can weaken the inhibitory effects of chloral hydrate, barbital, and chlorpromazine, and enhance the process of inhibition of the cerebral cortex; in acute tests, it only causes mild blood pressure reduction; in short, the dose that enhances the body's non-specific resistance, Does not cause significant changes in normal function. However, when the body's resistance is reduced or there is a special need for extra burden, it can increase the effectiveness of physical or intellectual work. Unlike amphetamines, they are not only less toxic, but also cause no excitement and do not disturb normal sleep.


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