For the first time in history, scientists have successfully transported targeted drugs into placental tissue.
May 13, 2016 Source: Bio Valley
Window._bd_share_config={ "common":{ "bdSnsKey":{ },"bdText":"","bdMini":"2","bdMiniList":false,"bdPic":"","bdStyle":" 0","bdSize":"16"},"share":{ }};with(document)0[(getElementsByTagName('head')[0]||body).appendChild(createElement('script')) .src='http://bdimg.share.baidu.com/static/api/js/share.js?v=89860593.js?cdnversion='+~(-new Date()/36e5)];It is estimated that 10% of pregnancies can cause serious complications, which can eventually lead to premature birth or other conditions, such as pre-eclampsia, where the mother usually experiences high blood pressure and fluid retention, and this series of conditions will affect the offspring. Growth. Many of the complications that occur during pregnancy are associated with abnormalities in the mother's placenta, and researchers cannot use a variety of methods to deliver the right level of nutrients to the placenta, or to maintain a good environment for fetal growth.
Due to the subtlety of the embryonic development environment, researchers are not able to use the appropriate methods to improve the environment of embryo development in the womb. Recently, a research paper published in the international journal Science Advances solved the problem for the first time. In the article, the researchers described how they successfully transported the drug into the placenta to enhance the function of the placenta. In this way, researchers can use this technology to successfully treat a range of diseases.
According to Lynda Harris, a researcher at the University of Manchester, the placenta behaves like a well-controlled tumor tissue, which grows fast, produces enough growth hormone and can escape the surveillance of the offline immune system. At present, many researchers have focused on developing special methods to transport drugs to tumor sites without affecting other functions of the body. Based on research in cancer, the researchers in this paper have a whimsy, the researchers said. If we can also selectively target the placenta in the same way, then by transporting the drug to the destination, it may improve the function of the placenta and effectively treat pregnancy complications in women.
The researchers then studied how the placenta reacts to two peptide molecules that target tumor tissue called CGKRK and iRGD; these peptide molecules act as special amino acid chains that can be used as micro drug transport capsules to help Drug delivery; after experiments with pregnant mice, the researchers found that just as these peptide molecules "target" tumors and successfully transport anticancer drugs to targets, researchers can also target placental tissue and Growth hormone is transported to the site of interest to improve the function of the placenta.
The researchers point out that these growth hormones have no effect on normal-sized mouse fetuses, and that fetuses that have abnormal body conditions due to abnormal placental function also respond to these growth hormones. The researchers wrote in the article that given the current lack of specific targeted drugs in the obstetric field, a specific targeted therapy that promotes fetal growth and does not induce other side effects may be able to meet current clinical treatment needs.
When researchers examined the function of the above-mentioned peptide molecules in human placental tissue, they found that these peptide molecules can bind to cells and penetrate into the cell membrane, which indicates that these peptides can also induce the same in the human body. The result of promoting embryonic growth. The biggest problem at the moment is that this therapy may be a risk for women with undiagnosed cancer, because the researchers are not sure whether these peptide molecules will target the placenta or tumor tissue, but the researchers said that it may be appropriate Screening methods to overcome these problems.
There is currently no suitable drug for the treatment of placental dysfunction, so if the doctor finds that the baby is not developing normally, the only way is to induce childbirth, and this study may help solve this problem; of course, the risk of premature birth is also very obvious, including Susceptibility to infection, cerebral palsy, and heart disease and diabetes in later life. Finally, the researcher Harris said that in the past 20 years only one drug was allowed to be used during pregnancy. In this paper, by establishing this new therapeutic platform, we may be able to develop a variety of new drugs and use them safely and effectively. Common or serious pregnancy complications in pregnant women.
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