(Original title: Antibiotics promote the growth of intestinal pathogens)
[Technology News] China Pharmaceutical Network in a new study, researchers from the University of California, Davis, and Saudi Arabia's King Abdulaziz University identified an in host-mediated intestinal carbohydrate The new mechanism of substance oxidation promoting the proliferation of pathogens after antibiotic treatment can explain how taking antibiotics changes the intestinal flora and increases the availability of nutrients that are beneficial to the growth of pathogenic bacteria such as Salmonella. The relevant research results were published online in the Nature Journal on June 15, 2016, and the title of the paper is "Host-mediated sugar oxidation promotes post-antibiotic pathogen expansion". The author of the paper is Andreas Bäumler, professor of medical immunology and microbiology at the University of California, Davis.
This study is important because changes in the gut flora are the basis for many human diseases, and the identification of a mechanism responsible for altering the microbial population is also developed to exploit the growth advantages of these pathogens after antibiotic treatment. A series of new therapies for the event opened the door. Franziska Faber, the first author of the paper, said, “Traditional research has focused on the mechanisms by which antibiotics help control bacterial growth, or to remind the development of new agents when bacteria develop resistance to existing drugs. However, our research is the first to confirm After antibiotic treatment, Salmonella can thrive in the intestine due to the increased availability of oxidized sugar."
Gastroenteritis is a common side effect of taking antibiotics. Although diarrhea may be mild and will improve after antibiotic treatment, in some cases it can cause colitis, or more serious symptoms: abdominal pain, fever and bloody diarrhea.
In this study, the researchers found that oral streptomycin (an antibiotic) increased the expression of inducible nitric oxide synthase (iNOS)-encoding genes in mouse cecum, and iNOS produced nitric oxide free radicals. And this free radical can oxidize galactose and glucose in the mouse cecum to galactarate and glucarate, respectively. Mucic acid and gluconic acid promote the growth of Salmonella Typhimurium in the intestine of mice. The use of genetic means to destroy the corresponding metabolic pathways can reduce the competitive advantage of Salmonella typhimurium. Bäumler said, “Classifiers have empirically used mucic acid as a feature of Salmonella isolates that cause gastroenteritis. This new study suggests that this property is used by Salmonella to thrive in the host gut. Part of the plan'.
[Technology News] China Pharmaceutical Network in a new study, researchers from the University of California, Davis, and Saudi Arabia's King Abdulaziz University identified an in host-mediated intestinal carbohydrate The new mechanism of substance oxidation promoting the proliferation of pathogens after antibiotic treatment can explain how taking antibiotics changes the intestinal flora and increases the availability of nutrients that are beneficial to the growth of pathogenic bacteria such as Salmonella. The relevant research results were published online in the Nature Journal on June 15, 2016, and the title of the paper is "Host-mediated sugar oxidation promotes post-antibiotic pathogen expansion". The author of the paper is Andreas Bäumler, professor of medical immunology and microbiology at the University of California, Davis.
This study is important because changes in the gut flora are the basis for many human diseases, and the identification of a mechanism responsible for altering the microbial population is also developed to exploit the growth advantages of these pathogens after antibiotic treatment. A series of new therapies for the event opened the door. Franziska Faber, the first author of the paper, said, “Traditional research has focused on the mechanisms by which antibiotics help control bacterial growth, or to remind the development of new agents when bacteria develop resistance to existing drugs. However, our research is the first to confirm After antibiotic treatment, Salmonella can thrive in the intestine due to the increased availability of oxidized sugar."
Gastroenteritis is a common side effect of taking antibiotics. Although diarrhea may be mild and will improve after antibiotic treatment, in some cases it can cause colitis, or more serious symptoms: abdominal pain, fever and bloody diarrhea.
In this study, the researchers found that oral streptomycin (an antibiotic) increased the expression of inducible nitric oxide synthase (iNOS)-encoding genes in mouse cecum, and iNOS produced nitric oxide free radicals. And this free radical can oxidize galactose and glucose in the mouse cecum to galactarate and glucarate, respectively. Mucic acid and gluconic acid promote the growth of Salmonella Typhimurium in the intestine of mice. The use of genetic means to destroy the corresponding metabolic pathways can reduce the competitive advantage of Salmonella typhimurium. Bäumler said, “Classifiers have empirically used mucic acid as a feature of Salmonella isolates that cause gastroenteritis. This new study suggests that this property is used by Salmonella to thrive in the host gut. Part of the plan'.
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