Recently, in 2016 organ chip Mobile Congress held in Boston, US CN biomedical company unveiled a $ 26 million human gut chip system. Although there have been biochips that collect liver, lungs, and a part of the intestines, the system exhibited for the first time connected seven major organ chips to achieve a highly mimicking of human physiology.
The fabrication of a single organ chip is similar to that of microchip fabrication, but with the addition of a porous membrane and nutrient solution that mimics human blood flow and cell growth. CN biomedical researchers said that the first consideration of the use of the chip system in new drug clinical trials is expected to replace the current drug testing volunteers and clinical animal experiments. At the conference, the team of Harvard University's Wyss Bioengineering Institute also said that it has a bone marrow chip that can test radiation research. In the future, reference will be made to CN Biotech's technology to produce a similar human body chip system for testing human body's response to nuclear waste.
As a new technology emerging in recent years, organ chips have been listed by the World Economic Forum as one of the top ten emerging technologies in 2016, and have been included in the blockchain, driverless, and artificial intelligence ecosystems. Analysts believe that in life science research, biochip technology is another revolutionary technological breakthrough after gene cloning and automatic gene sequencing technology. It has broad application prospects in medical research and clinical drug design.
Many foreign research teams have begun to use organ chips for drug development and synthesis, virus testing and drug screening. At the beginning of this year, Vanderbilt University in the United States developed an alternative artificial kidney chip, which can be used to completely remove dialysis troubles from patients with kidney disease after implantation into the body. Relevant human experiments are expected to start at the end of 2017. At the same time, the US Department of Defense has great interest in biochips. At a conference hosted by the American Society for Microbiology, microbiologists at the Pacific Northwest National Laboratory said that research has begun on the implantation of anthrax virus into rabbit lung chips. At the same time, the US Department of Homeland Security is willing to use the human body chip system for anthrax testing.
China has also carried out research and development in the field of biochips. For example, the Dalian Institute of Chemical Physics of the Chinese Academy of Sciences has used the chip technology to construct a tumor cell culture model. The Yangtze River Securities Research Report believes that the biochip market is expanding at a compound annual growth rate of 19%. At present, the total sales of biochips in China exceeds 300 million yuan, and have been exported to 14 countries and regions such as the United States and Europe. China's biochips are mainly concentrated in the field of gene chip and DNA chip detection. With the continuous maturity of technology and the expansion of research fields, the biochip industry has great commercial potential in the future.
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