The article "Building a Sustainable Chinese Medicine Innovation Ecosystem" points out that medical innovation is the fundamental need to solve people's livelihood problems. Medical innovation can provide long-term motivation for economic sustainability. Medical innovation reflects the country's core competitiveness.
Since the reform and opening up 40 years ago, the level of innovation in China's pharmaceutical industry has been continuously improved, especially in the past five years, the domestically produced innovative drugs have been reported frequently. Driven by policies, talents and capital factors, China's innovative drugs will enter a period of rapid development. Some insiders predict that between 2018 and 2020, 15 to 20 independent innovative drugs will be approved at a rate of 4 to 6 per year, and local enterprises will continue to activate the market.
Pioneer: from imitation to innovation
Birth of artemisinin
In the 1960s, China's material conditions were extremely backward, scientific research equipment was rudimentary, and talents were scarce, which was plagued by the reality of lack of medical care and medicine. In order to encourage enterprises to develop and produce varieties that have been listed abroad and that are not available in China, the “created and copied†drugs are called “new drugsâ€. Even after a long period of time, the concept of “new drug†still stayed in the era of generic drugs. Changing a package or changing a dosage form, changing a tablet into a capsule is a new drug.
In this context, the birth of artemisinin, the internationally original innovative drug widely recognized in the world, is very precious.
It was still extremely difficult. In the early 1970s, more than 40 key scientific research units and medical colleges and universities across the country participated in the project. The active ingredient of anti-malaria was extracted from the yellow sage, named "artemisinin". From artemisinin to derivative series, from artemisinin monotherapy to compound, from artemisinin laboratory to industrial scale production, to artemisinin antimalarial new drug mass production and market, it lasted for 15 In the year, the efficiency and speed of research and development of this innovative drug were very rare at home and abroad.
As a prominent contributor to the discovery of artemisinin, the researcher of the Chinese Academy of Traditional Chinese Medicine, Tu Yu, won the 2015 Nobel Prize in Physiology or Medicine for this achievement and became the first Chinese to win the Nobel Prize in Natural Science.
Ren Dequan, former deputy director of the State Food and Drug Administration, recalled that “the development of artemisinin successfully mobilized the national strength and was the result of a single new drug project. Although at that time, enterprises and research institutes explored new drug development, but at the national level. The development of innovative medicine as a career was in the 1990s."
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