Pharmacological effects
1. Liver protection, gallbladder effects: The product contains d-catechin and epicatechin tea have significant hepatoprotective effect. D-catechin 150mg/kg gavage protection of liver injury caused by carbon tetrachloride, can significantly reduce the alanine aminotransferase (ALT), reversed albumin/globin (A/G) reversal, increase Glutathione S-transferase (GST) activity enhances liver detoxification. D-catechin can antagonize liver damage caused by muscarinine, phalloidine, and acetaminophen, and it can be used to treat hepatic steatosis and low-protein and high-fat diets induced by homocysteine ​​thioether S and malonic acid in rats. The subcutaneous injection of 50 mg/kg of hepatic steatosis in rats induced by subcutaneous injection of catechin also had obvious protective effect, while the liver fat of d-catechus caused by uracil-6-carboxylic acid or ethanol could also be significantly prevented. The. The hepatoprotective effect of D-catechin is related to its promotion of intrahepatic ATP synthesis, lysosomal membrane stability, free radical scavenging, antioxidant effects, and possible anti-endotoxin and anti-fat infiltration. The protective effect of this tea essence on the liver is also related to its strong free radical scavenging effect. The duodenal administration of 50 mg/kg or 75 mg/kg catechins also significantly increased the bile flow in anesthetized dogs or rats for 3 h or 60-80 min.
2. Effects on immune function: d-catechin does not affect leukocyte migration in the absence of antigen, but in vitro tests inhibit the migration of normal human leukocytes sensitive to the purified protein derivative (PPD) antigen, whereas it has been associated with hepatitis B infection. Patients who are sensitive to hepatitis B surface antigen have a stronger inhibitory effect on leukocyte migration, indicating that they can amplify cell-mediated immune responses and promote the clearance of hepatitis B antigen. D-catechin also restores normal lymphocyte counts in patients with chronic hepatitis and promotes the conversion of lymphocytes in patients with chronic tuberculosis-positive chronic liver disease induced by PPD. For normal human peripheral blood Ts cells, d-catechin can be activated and inhibit concanavalin A (ConA)-induced blast cell transformation, but d-catechin in patients with chronic livelihood significantly inhibits Ts function, inhibiting Ig generation.
3. Antimicrobial activity: In vitro bacteriostatic tests showed that the minimum inhibitory concentration (MIC) of catechu was 2.81 mg/ml for Staphylococcus aureus, 5.63 mg/ml for Staphylococcus aureus, and 5.63 for Streptococcus hemolyticus. Mg/ml, 5.63 mg/ml of Candida albicans, also reported on catechu Pseudomonas aeruginosa, diphtheria bacilli, proteus. Shigella, typhoid bacillus and other inhibitory effects. The susceptibility of 5% catechu suspension to 68 strains of Shigella was 100% sensitive to both Freud and B. baumannii. In addition, it also has a significant inhibitory effect on viruses and certain fungi.
4. Inhibition of intestinal movement and anti-diarrhea effect: pediatric tea irrigation, can inhibit the fasting rabbit duodenum and small intestine movement, promote cecal retroversion, but no significant effect on the colon. D-catechin also inhibits amine-producing enzymes in the bacteria in the large intestine, blocking the production of terpenoids and causing constipation.
5. Hypoglycemic effect: Indian folk tea used in the treatment of diabetes, the product contains catechu tea can make ATP, temperature and concentration-dependent promotion of rat insulin secretion, 30mg/kg twice daily, a total of 4d can make rats Insulin is increased by 30% in islets, and epigallocatechin also promotes DNA synthesis in islets. D-catechin also has a hypoglycemic effect on rabbits.
6. Effects on Blood and Cardiovascular System: The catechu extract has significant anti-platelet aggregation and antithrombotic effects, and has a concentration-dependent inhibition of catechus in ADP, AA, and collagen-induced platelet aggregation in rabbits; It also significantly inhibited thrombosis in rats, and decreased TXA2 content without significant effect on 6-Keto-PGF1a. D-catechin can delay the increase of serum cholesterol due to lanolin. In addition, two isomers were also obtained from catechu and had cholesterol-lowering activity. D-catechin can cause isolated rabbit ear vasoconstriction, and the isolated heart is first inhibited and then excited. Intravenous pediatric tea can reduce skeletal muscle tension in guinea pigs, lower blood pressure, and increase respiration. The activity of tyrosinase, d-catechin, can be enhanced, while the activity of tyrosine decarboxylase is inhibited, thereby reducing the level of adrenaline in the body, which may be related to the antihypertensive effect. D-catechin inhibits oxygen uptake in a variety of tissues such as the brain, liver, kidney, heart and pig aorta in rats and is evident in the heart.
7. Other effects: 30mg subcutaneously immersed in tea, can significantly delay the latency of acetic acid-induced writhing in mice, significantly reduce the number of writhing, subcutaneously immersed in 40mg tea catechu 5h no obvious stimulation, indicating that there is a certain catechu Analgesic effect. In vitro catechu has inhibitory effects on Ehrlich ascites carcinoma. Catechin has anti-radiation, white blood cell and anti-tumor effects, and can prevent the proliferation of tumor cells by inhibiting the adhesion of tumor cells and fibrin. Vitamin C deficiency in guinea pigs can promote absorption of vitamin C and inhibit the formation of bladder stones in experimental rats, which may be related to its ability to lower the pH of urine.
8. In vivo process: [14C]d-catechin is orally administered, and the absorption rate is above 70%, peaking at 1-3h. Oral doses of 0.5 g, 1.0 g, and 2.0 g were high and low depending on the dose, but the relative bioavailability was similar, with no gastrointestinal saturation absorption and dose-dependent first-pass effect. The apparent elimination half-life of the original compound was 1-1.5 h, about 0.5% of which was excreted from the urine as the original form, and excretion was completed after about 8 h.
9. Toxic catechins: The mice were killed by intravenous injection of 200-300 mg/kg, and rats fed 3%-5% diets containing catechins for 1 month did not cause animal death. The LD50 of catechins was greater than 1.37g/kg for mice.
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