Pharmacological effects
Theory One
1. Hypotensive, diuretic, dilated blood vessels: anesthetized dogs and cats are treated with 0.4-0.5g/kg gavage of Mulberry decoction, or 0.1-0.25g/kg intravenously, all have antihypertensive and diuretic effects. 1. The isolated rabbit ear blood vessels have an expanding effect on cholesterol arteriosclerosis.
2. Anticonvulsant: Mulberry decoction has a sedative effect on caffeine-induced mouse excitement. Can delay the death of mice caused by pentazole convulsions.
3. Anti-virus: 10% decoction or infusion inhibits poliovirus.
4. Antithrombotic: Mori parasitic decoction 0.1g/ml and the aqueous phase extracted by ether 0.13g/ml, rabbit blood in vitro test, all have significant antithrombotic effect.
5. Toxicity: The LD50 of mice injected with Morinda decoction is 11.24g/kg.
Theory two
1. Antihypertensive effect: The ethanol extract of the fresh fruit of Echinocereus sinensis was formulated as a 10% solution of physiological saline. Intravenous injection of 1mL/kg to dogs and rabbits reduced blood pressure by an average of 32% and maintained for 3 minutes. Intraperitoneal injection of 5mL/kg, blood pressure to maintain more than 1h. Ginkgo has also significant antihypertensive effect, and its short-term antihypertensive components are choline, acetylcholine, and propionylcholine. The long-lasting antihypertensive component is a mistletoe. Traditional Chinese medicines that can change enkephalin content are rarely reported, and mistletoe is one of them. Its concentrated decoction can restore normal blood pressure and enkephalin content in brain regions of deoxycorticosterone acetate-induced hypertensive rats, indicating that mistletoe abnormalities of central enkephalin in DOCA-induced hypertensive rats Regulatory effect. The mechanism of antihypertensive action of mistletoe is not yet clear. It may be caused by the inhibition of the vasomotor center of the medulla oblongata. It may also be caused by the reflexive inhibition of the vasoconstrictor center by acting on the endoreceptors of the circulatory system. It is also believed that the ginkgo mistletoe water The extract has the characteristics of cholinergic antihypertensive effect.
2. Anti-arrhythmia: Mistletoe has different effects on arrhythmia caused by different causes. With atrial fibrillation and ventricular premature beats the best effect. In terms of etiology, the drug has better arrhythmia caused by myocardial infarction and has an effective rate of 75%. It also has a certain effect on arrhythmia caused by myocarditis sequelae, with an effective rate of 71.4%. It has a heart rhythm caused by coronary heart disease and angina pectoris. The effect of abnormalities was slightly poor, with an effective rate of 57.1%. With the extension of treatment, the effectiveness has also improved.
Wu Jixiong et al. Observed the effect of flavonoid glycosides of Vulgaris on rat skin cells and guinea pig ventricular myocytes by means of glass electrode and selective membrane channel blockers. The results showed that 100μg/mL mistletoe accelerated the recovery of FAP. The extreme process increases the delta ERP/ΔAPD ratio, which is related to the reduction of slow inward ion currents and the increase of time-dependent potassium currents. It is suggested that the anti-tachyarrhythmia of mistletoe is related to its relative prolongation of ERP elimination.
3. Increase coronary blood flow, improve coronary circulation, and increase cardiac contractility: Experimental studies have shown that mistletoe increases the coronary flow and improves coronary circulation in both normal and vibrating hearts, both for whole animals and for isolated hearts. effect. Mistletoe can increase coronary flow mainly through direct expansion of coronary artery, so mistletoe is more suitable for coronary heart disease patients with hypertension and tachycardia. It is valuable as a drug for improving coronary circulation. It has also been reported that mistletoe injection can significantly or very significantly affect the duration of systole in normal anesthetized dogs and acute myocardial infarction dogs, in which the shortening of the pre-ejection shortening, the prolongation of left ventricular ejection time, and the decrease of the ratio of PEP/LVET are the most obvious, indicating that Parasitism can significantly improve right ventricular systolic function.
4. Decreased myocardial oxygen consumption: Mistletoe significantly reduced oxygen consumption, regardless of whether the self-control or between-group controls had significant significance (P<0.05). Zhu Shunhe and others have demonstrated that mistletoe can significantly reduce the cAMP content in ischemic myocardium, decrease the A/G ratio, and inhibit the metabolic and electrophysiological disorders caused by excessive cAMP increase. Therefore, it is a hopeful Chinese medicine for protecting the heart. .
5. Inhibition of platelet aggregation, anti-thrombosis, and improvement of microcirculation: The total glucosides of mistletoe can inhibit the aggregation of platelets and prevent the release of active substances, thereby avoiding vasoconstriction and thrombosis. In vitro and in vivo experiments demonstrated that the mistletoe had a significant inhibitory effect on ADP-induced platelet aggregation. It also has an inhibitory effect on experimental thrombosis in rats. Inhibition of thrombosis was most marked by intravenous injection of 10.0 mg/kg. The inhibition rate was 57% after 5 minutes, and the inhibitory effect lasted for 0.5 h. Zhu Weimin et al. observed 48 patients with old myocardial infarction. After treatment with mistletoe injection, the microcirculatory disturbance was significantly improved. The flow rate of microcirculation flow from cloud flocculation to linear flow accounted for 64% to 86%. It can make micro-vascular recanalization, increased micro-blood flow, leukocyte disaggregation, platelet aggregation rate decreased, change the clinical "bloody stasis" and improve the heart function in patients with coronary heart disease. Mistletoe inhibits the production of platelet TXA2 and does not affect the formation of EC in the blood vessel wall. Therefore, it can improve the balance of PGT2-TXA2 lost in patients with coronary heart disease and achieve the purpose of preventing and treating coronary heart disease. Cai Weijing et al. demonstrated that mistletoe can inhibit platelet aggregation and TXA2 release in humans, and studied the effect of mistletoe on human umbilical vein endothelial cells and functions in vitro, and evaluated its clinical value. It was demonstrated that different concentrations of mistletoe have different effects on endothelial cells.
6. Anti-tumor effects: The main components of Ginkgo biloba are proteins, polysaccharides, lipids and glycoproteins, which have a direct cytostatic effect. Both in vitro and in vivo have shown that mistletoe has no special effect on malignant tumors with other cytostatic agents, and its antitumor effect is 10 times more powerful than cyclophosphamide. Nichaus et al. studied the presence of mistletoe protein in mice to prevent tumors and stimulate thymus production. Using a subtoxic dose of iv or ip, 200 mice were dissected and the spleen and thymus cells became a significant proliferation. The mistletoe protein can inhibit the migrating tumor cells, and it is most effective to perform preventive injection before the tumor cells migrate. A variety of protein components are isolated from Mistletoe, and antitumor activity is exhibited at very small doses. Their tumor suppressing effects are not related to their toxicity, and proteins with very weak denaturation also have anti-cancer effects. Anti-cancer mechanism is to interfere with the genetic information of cells, showing selective inhibition of DNA levels, and has specific effects on malignant HeLa cells and benign amniocytes. Mistletoe has an adjuvant effect on mouse antibody formation and SRPC-induced delayed hypersensitivity reaction. This plant juice can stimulate MPS and induce inflammatory reaction, which may be an important mechanism for cancer immunotherapy.
The indications for the treatment of cancer by mistletoe are very broad. Not only is it suitable for precancerous conditions, but it is also suitable for preventing postoperative recurrences. Follow-up observations are made on the efficacy of postoperative treatment of breast cancer. There are 319 cases in the treatment group and 253 cases in the control group. The results showed that the treatment group improved significantly in all aspects, and compared with the best results in the world literature after 5 years, it was still higher than the average level after 10 years. In addition, it is also suitable for advanced tumors that are inoperable, can prolong life, improve general patient symptoms, relieve pain, relieve the course of the disease, and rarely require regular use of analgesics for very severe cases. In addition, postoperative gastric cancer, colon cancer, and lung cancer all improved survival. It has good curative effect on stage III ovarian cancer, advanced rectal cancer, colon cancer and bladder cancer. The total alkaloids of mistletoe also have anti-tumor effects. In addition to the strong inhibitory effect on primary transplanted tumors of animals, mistletoe total alkaloids also have a significant role in inhibiting tumor cell metastasis.
7. Treatment of hepatitis: mistletoe treatment of hepatitis B has a certain effect. There have been 34 cases of HBsAg-positive hepatitis treated with mistletoe, 10 cases of negative conversion, and the remaining 24 cases of HBsAg titers have decreased to varying degrees. Oleanolic acid contained in mistletoe has the effect of eliminating non-specific inflammation and edema in the liver. The flavonoids can also expand blood vessels in the liver and increase hepatic blood flow to enable hepatocytes to repair toxicity. Therefore, mistletoe can also be used to treat hepatitis. The Chinese medicine is utilized. It has also been reported that the mistletoe has a cell agglutination activity and an anti-exudative effect, excitates the uterus, and reduces cholesterol-induced atherosclerotic plaque formation.
Theory Three
1. Antihypertensive effect of the product's water leaching solution, ethanol - water leaching solution, 30% ethanol leaching solution, have reduced blood pressure in anesthetized animals. Anesthetized cats and dogs were treated with 0.4 to 0.5 g/kg gavage of the leaves and leaves of Mulberry Mulberry, or intravenously at 0.1 to 0.25 g/kg, all had antihypertensive effect and maintained for a long time. Tolerance phenomenon, cut off the vagus nerve or injection of atropine can only weaken but can not completely eliminate its antihypertensive effect, no antagonistic or enhancing effect on epinephrine, blood pressure and sinus nerve has nothing to do. The principle of this antihypertensive effect has been reported as central or reflex, that is, due to central sedation and reduced sympathetic and vasomotor center excitability; or acting on endoreceptors, causing hypotensive reflexes. the result of.
Alcohol extracts, stems and leaves of fresh mistletoe leaves also have antihypertensive effect, the latter combined with hawthorn, garlic, stinkbug, its antihypertensive effect is greatly enhanced, the role of time has also been extended. For the principle of this kind of antihypertensive effect, it is generally believed that the mistletoe stimulates the circulatory system's internal receptors, inhibits the vasomotor center through vagal afferent fibers, and produces antihypertensive effect. Cut off the vagus nerve of the animal, that is no longer cause blood pressure; and atropine-treated animals, it can only eliminate its role in slowing down the heart rate, but can not eliminate its antihypertensive effect.
The flat storks have a temporary antihypertensive effect on anesthetized dogs and are susceptible to rapid tolerance.
2. Sedative effect of intraperitoneal injection of Mulberry Mushroom 2g/kg can inhibit the caffeine-induced excitement and prolong the death time of mice induced by pentylenetetrazol.
3. Diuresis has a more pronounced diuretic effect of L. parasitica. Anesthetized dog intravenous injection of 0.5mg/kg can cause diuresis, and the dose increase is more significant. In chronic rat experiments, there is significant diuretic effect regardless of oral or injection. The diuretic effect is not as strong as aminophylline, but its toxicity is only 1/4 of aminophylline, so the treatment rate is large.
4. The effect of cardiovascular on normal pulsatile and vibrated isolated guinea pig heart samples, Sansha (granules) have the role of relaxation of coronary blood vessels, increase coronary flow, and can combat pituitrin. Experiments have shown that: total flavonoids 20 ~ 25mg that has a sustained expansion of coronary and cardiac effect, its concentration of 1% that can increase the coronary flow in isolated guinea pig heart 2 ~ 3 times, and does not seem to increase myocardial oxygen consumption. Myocardial contractility is first suppressed and then increased. There is no direct dilatation of normal isolated rabbit ear blood vessels, but the isolated rabbit ear blood vessels of cholesterol-induced arteriosclerosis have obvious direct expansion.
5. The role of anti-pathogenic microorganisms Sansha decoction in vitro (monkey kidney monolayer epithelial tissue culture) on the poliovirus and some enteric viruses have a significant inhibitory effect. Poliovirus is directly inactivated by direct contact with the drug for one hour, which is inhibited. In vitro can inhibit the growth of Salmonella typhi and Staphylococcus.
We are the one of three leading factory in China, specialized in manufacturing laser distance module since 2004. Bilateral laser distance measurer is one of mutifunctional laser distance device. JRT multifunctional laser measuring device functions include area,distance,length,volume,continuous measurement,addition and subtraction, measuring unit: ft/m/inch. More functions can be customerized. And the laser measuring meter have distance 30/40/60/80/100/150m for chosing. This bilateral degin is our 40m middle laser distance transducer 703A laser measuring meter.
OEM service:
* usb chargable
* voice
* IP54 rating
* Colorful case
Laser Range Finder Measurer,80M Laser Distance Meter,Distance Meter 80M,Laser Distance Meters
Chengdu JRT Meter Technology Co., Ltd , https://www.rangingsensor.com