In 2016, Dr. Dieckmann of the University of Waterloo in Canada and his team used NMR spectroscopy to detect the minimum CaM concentration and the increasing CaM concentration combined with the NOS peptide conformation, and combined with the SPR technique, found that when the CaM concentration increases, the interaction The strength is also enhanced and leads to a conformational change in the protein.
The SPR data plays a key role in determining the enhancement of interactions. In addition, the SPR study yields Kon, and the Koff value reveals Ca2+ concentration-dependent binding kinetics and obtains more details about the interaction. Using these results, Dr. Dieckmann and his colleagues were able to reveal a subtle change in the structure of the previous excessive calcium concentration experiment by conformational studies under more realistic physiological conditions. The article was published on Biochemistry and highly evaluated the performance of OpenSPR:
"I think the SPR data is really what made this paper able to get into a good journal. You have to be able to correlate structure to function, and SPR really allowed us to show that these dynamics have real world consequences in terms of how easily The protein binds and comes off its target protein, and I think that's really the key that pushed this paper to the next level." - Dr. Dieckmann
Compared to other Pull-down detection technologies that can only perform endpoint detection, SPR label-free technology allows researchers to quantitatively analyze Kon, Koff and KD values ​​of biomolecular interactions, providing deeper insight into intermolecular interaction studies. analysis.
The role of SPR technology in life science research is becoming more and more important, and has attracted much attention in many medical and medical research. Articles with SPR data are also among the best journals. I believe that SPR data will make your Paper more persuasive and influential!
OpenSPR is a friendly, low-maintenance, desktop-based SPR solution that is used by hundreds of scientists and can get the quality you need with the SPR technology at your fingertips. Data, speed up your research and publishing articles!
Nicoya Personal Molecular Interaction Instrument Technology Advantages:
ï¶High performance---Biomolecular or small molecule ï¶ Easy to operate--- Half an hour to control ï¶ Low cost of experiment--- Low cost instrument and chip ï¶ No maintenance cost --- Simple and stable optical system Detection efficiency --- loading, results, one-click analysis, high stability - negligible bulk effect, independent of buffer refractive index and temperature changes
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