Improve the medical experience of new drug monitoring systems or replace blood draws

Release date: 2016-10-10

In order to accurately understand the concentration of the drug in the patient, sometimes doctors need to frequently draw blood from the patient. Frequent blood draws bring great pain to the patients. But recently, scientists at the University of British Columbia and the Paul Scherrer Institute in Switzerland have created a new drug monitoring system that can replace current blood-sucking monitoring methods to improve patient experience. .

This system contains a small patch with a small pin that is less than 0.5 mm long. Because of the extremely short length of these small needles, they can only penetrate the outermost layer of the skin and cannot reach the dermis layer that is covered with nerves and blood vessels. In other words, these small needles are painless.

This patch is painless because it does not touch blood vessels and nerves.

By design, when the patch is attached to the arm, the needle can acquire the tissue fluid under the epidermis, and the sensor analyzes the concentration of the drug in the patient. Due to the "mini" size of these needles, they require only one part per million of tissue fluid.

“This is perhaps one of the smallest medical analysis tools I have ever seen,” said Dr. Urs Hafeli, associate professor of pharmacy at the University of British Columbia.

After the concept is formed, the next thing to do is to test the sensitivity of the system. Sahan Ranamukhaarachchi, a Ph.D. student at the University of British Columbia, worked with the research team to analyze whether the monitoring system could effectively analyze drug concentrations in patients. The results of the study made them very excited – still taking vancomycin as an example, the threshold for routine kit monitoring is 1.35 μM, and the new monitoring system using “microneedles” is 10 times more sensitive.

“Many research groups are developing microneedle technology that can administer painless vaccines and deliver drugs,” Sahan said. “But it is a whole new idea to use microneedles to monitor drug concentrations.”

Currently, Microdermics of Canada is promoting the development of this product. After demonstrating the potential for monitoring vancomycin, researchers look forward to using it for other drug monitoring processes.

Source: Health New Vision

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